Immunity
Peptides
Compound profile

Thymosin Alpha-1: Immunomodulatory Peptide

Thymosin Alpha-1 (Tα1) is a 28-amino-acid immunomodulatory peptide originally isolated from thymus tissue.

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What it is

Tα1 (Zadaxin in clinical use in some jurisdictions) is a synthetic 28-amino-acid peptide originally characterised from thymus extracts. Approved in several countries for hepatitis B, hepatitis C, and as an immune adjunct in oncology.

Evidence snapshot

Category: Immunity. Status: Mixed. See the references section below for the underlying primary sources.

Mechanism

Modulates T-cell maturation and function, dendritic cell activity, and cytokine production. Acts as an immune ‘normaliser’ rather than a simple stimulator.

Key research findings

Clinical trials have demonstrated efficacy in chronic hepatitis B and as an adjuvant in immunocompromised populations.

Limits of the evidence

Not approved by FDA or EMA. Off-label and research use in longevity contexts lacks rigorous evidence.

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