Tissue Repair
Peptides
Compound profile

TB-500 (Thymosin Beta-4 fragment): Actin Sequestration & Tissue Repair

A look at the synthetic fragment of Thymosin Beta-4 — the dominant actin-sequestering peptide in many mammalian cell types — and its role in cell migration, wound healing, and cytoskeletal dynamics.

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What it is

TB-500 is the laboratory name for a synthetic fragment of Thymosin Beta-4 (Tβ4), specifically the central actin-binding domain comprising amino acids 17–23 of the parent 43-residue protein.

Evidence snapshot

Category: Tissue Repair. Status: Preclinical. See the references section below for the underlying primary sources.

Mechanism

TB-500 / Tβ4 sequesters G-actin (monomeric globular actin) in a 1:1 stoichiometry, maintaining a pool of unpolymerised actin for rapid cytoskeletal remodelling — essential for cell types that need to reorganise their cytoskeleton quickly.

Key research findings

Across published work, Tβ4 has been shown to accelerate wound healing in rodent and porcine models, improve corneal epithelial healing, promote cardiac recovery in rodent post-MI models, and stimulate hair follicle cycling.

Limits of the evidence

Most published work uses the full-length Tβ4 protein rather than the TB-500 fragment specifically. TB-500 is on the FDA peptide watch-list and is classified by WADA as a prohibited substance.

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Tissue Repair

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Tissue Repair

TB-500 (Thymosin Beta-4 fragment)

Synthetic fragment of Thymosin Beta-4, a 43-amino-acid peptide investigated for its role in actin regulation, cell migration, and wound healing.
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Peptide Protocols

BPC-157 + TB-500

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