Cognition
Peptides
Compound profile

Semax: ACTH(4-7) Analogue and Neuroprotection

Semax is a synthetic heptapeptide analogue of ACTH(4-7) developed in Russia, studied for neurotrophic and neuroprotective effects.

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What it is

Semax is a synthetic heptapeptide analogue of ACTH(4-7) developed at the Institute of Molecular Genetics (Russian Academy of Sciences) and approved in Russia.

Evidence snapshot

Category: Cognition. Status: Preclinical. See the references section below for the underlying primary sources.

Mechanism

Modulates expression of BDNF and NGF in the hippocampus and cortex. The mechanism involves melanocortin receptor-independent pathways distinct from ACTH itself.

Key research findings

Studied in rodent models of stroke, traumatic brain injury, and cognitive function. Limited clinical work in Russian populations for cognitive enhancement and recovery from ischemic stroke.

Limits of the evidence

Most published work is from Russian research groups. Clinical evidence base outside Russia is minimal.

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