Cognition
Peptides
Compound profile

Selank: Tuftsin Analogue and Anxiolytic Research

Selank is a synthetic heptapeptide analogue of tuftsin, developed and approved in Russia as an anxiolytic and nootropic agent.

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What it is

Selank is a synthetic heptapeptide based on tuftsin with a C-terminal extension. Developed at the Institute of Molecular Genetics (Russian Academy of Sciences).

Evidence snapshot

Category: Cognition. Status: Preclinical. See the references section below for the underlying primary sources.

Mechanism

Modulates serotonergic and BDNF expression. Also affects GABAergic signalling. Anxiolytic effects attributed to serotonin turnover modulation and BDNF upregulation.

Key research findings

Studied in rodent anxiety models and limited Russian clinical populations for generalised anxiety disorder and cognitive enhancement. Approved in Russia.

Limits of the evidence

Most published work is from Russian research groups. Independent replication outside Russia is sparse.

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