Longevity
Peptides
Compound profile

NAD+ Precursors (NMN / NR): Longevity Research

NAD+ precursors — principally NMN and NR — are studied for effects on NAD+ levels, sirtuin activity, and mitochondrial function.

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What it is

NMN and NR are both biosynthetic precursors to NAD+ (nicotinamide adenine dinucleotide). NAD+ levels decline with age in many tissues.

Evidence snapshot

Category: Longevity. Status: Mixed. See the references section below for the underlying primary sources.

Mechanism

Both NMN and NR are converted to NAD+ through distinct salvage pathways. Elevated NAD+ supports sirtuin function, PARP activity, and other NAD+-dependent enzymes.

Key research findings

Preclinical work in rodents has shown beneficial effects on metabolic function, vascular health, and several ageing biomarkers. Early human trials have demonstrated safety and NAD+ elevation.

Limits of the evidence

Long-term human outcome trials are limited. Effects in healthy adults versus disease populations may differ.

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