Endocrine
Peptides
Compound profile

Kisspeptin: Neuropeptide of the HPG Axis

Kisspeptin is a family of neuropeptides encoded by the KISS1 gene, with critical roles in reproductive hormone regulation through GnRH pulse generation.

On this page

What it is

Kisspeptins are a family of neuropeptides processed from the KISS1 gene product. Kisspeptin-54 and the shorter kisspeptin-10 are the most studied fragments.

Evidence snapshot

Category: Endocrine. Status: Mixed. See the references section below for the underlying primary sources.

Mechanism

Binds the KISS1R (GPR54) receptor on GnRH neurons, triggering GnRH release. GnRH pulses drive LH and FSH release from the pituitary. Kisspeptin is the master regulator of GnRH pulse generation.

Key research findings

Clinical research has demonstrated kisspeptin’s role in reproductive disorders including hypothalamic amenorrhea, hyperprolactinemia-related hypogonadism, and delayed puberty.

Limits of the evidence

Pharmacological development has been challenging due to short half-life of native kisspeptin. Modified analogues with extended half-life are under investigation.

Continue reading

Tissue Repair

BPC-157

Synthetic pentadecapeptide derived from a gastric juice protein, studied across hundreds of preclinical reports for tissue regeneration and cytoprotection.
Read Guid
Tissue Repair

TB-500 (Thymosin Beta-4 fragment)

Synthetic fragment of Thymosin Beta-4, a 43-amino-acid peptide investigated for its role in actin regulation, cell migration, and wound healing.
Read Guid
Peptide Protocols

BPC-157 + TB-500

Combined tissue-repair peptides with complementary mechanisms — the synergy hypothesis examined critically against the available preclinical record.
Read Guid
Growth Hormone · Research

Ipamorelin

Selective pentapeptide agonist of the growth hormone secretagogue receptor (GHSR-1a) studied for targeted GH release with minimal effect on cortisol, ACTH and prolactin.
Read Guid