Cognition
Peptides
Compound profile

Dihexa: Angiotensin IV Analogue and HGF/c-Met

Dihexa is a synthetic angiotensin IV analogue developed as a potent hepatocyte growth factor (HGF) / c-Met receptor agonist.

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What it is

Dihexa is a synthetic hexapeptide developed at Washington State University. Derived from angiotensin IV but engineered for c-Met binding rather than AT4/IRAP.

Evidence snapshot

Category: Cognition. Status: Preclinical. See the references section below for the underlying primary sources.

Mechanism

Potently activates the c-Met receptor (the HGF receptor), triggering downstream signalling that promotes synaptic plasticity, dendritic spine formation, and neuronal survival.

Key research findings

In rodent models, dihexa enhances learning and memory, including in models of cognitive decline and traumatic brain injury.

Limits of the evidence

Very limited published work. Mechanism specificity needs more characterisation. Off-label use in nootropic contexts is widespread

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